Sickle Cell Disease

This groundbreaking book chronicles the history of sickle cell anemia in the United States, tracing its transformation from an "invisible" malady to a powerful, yet contested, cultural symbol of African American pain and suffering. Set in Memphis, home of one of the nation's first sickle cell clinics, "Dying in the City of the Blues reveals how the recognition, treatment, social understanding, and symbolism of the disease evolved in the twentieth century, shaped by the politics of race, region, health care, and biomedicine. Using medical journals, patients' accounts, black newspapers, blues lyrics, and many other sources, Keith Wailoo follows the disease and its sufferers from the early days of obscurity before sickle cell's "discovery" by Western medicine; through its rise to clinical, scientific, and social prominence in the 1950s; to its politicization in the 1970s and 1980s. Looking forward, he considers the consequences of managed care on the politics of disease in the twenty-first century. A rich and multilayered narrative, "Dying in the City of the Blues offers valuable new insight into the African American experience, the impact of race relations and ideologies on health care, and the politics of science, medicine, and disease.

Renaissance of Sickle Cell Disease Research in the Genomic Era

Sickle-cell disease - Sickle cell disease is a general term for a group of genetic disorders caused by sickle hemoglobin (Hgb S). In many forms of the disease, the red blood cells change shape upon deoxygenation because of polymerization of the abnormal sickle hemoglobin.

Mast cell disease - Mast cell diseases comprise a heterogeneous spectrum of diseases involving the mast cells. The most common variants are:

Autosplenectomy - An autosplenectomy occurs when a disease damages the spleen to such an extent that it is non-functioning and so equivalent to the spleen having been surgically removed (splenectomy). This may occur in sickle-cell disease and spherocytosis.

Asplenia - ... and is associated with some risks. Asplenia may be congenital (congenital asplenia), or acquired through surgery (splenectomy) or through processes that destroy the spleen, generally through its function to filter the blood and therefore referred to as autosplenectomy (eg spherocytosis and sickle-cell disease).

sicklecelldisease

Mast Cell Disease - Mast Cell Disease Mast Cells And Basophils - No 271 The book presents recent advances relating to the factors mast cell disease and mechanisms that regulate the growth, differentiation mast cell disease and function of mast cells mast cell disease and basophils; discussion of new technologies used to study these cells, mast cell disease and integration of the basic scientific findings in the context of therapeutic possibilities for the treatment of diseases such as allergic inflammation mast cell disease and autoimmune disease ...

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